In Huajuapan de León, visitors can explore a variety of cultural and historical attractions that reflect the town's rich heritage. One notable site is the Parish of Santa María de la Asunción, which showcases impressive colonial architecture and features beautiful altarpieces. The town square, or Zócalo, serves as a central gathering place and is ideal for experiencing local life, with nearby cafes and shops offering a glimpse into the everyday activities of residents.

For those interested in history, the Museum of the Battle of Huajuapan provides insight into the region's role during the Mexican War of Independence, with exhibits that highlight significant events and figures. Additionally, the Archaeological Zone of Teposcolula is a short drive away, where visitors can explore ancient ruins and learn about the Mixtec civilization.

Local cuisine is another highlight of Huajuapan, with traditional dishes such as mole verde and tlayudas available at various eateries. Engaging with local markets, where fresh produce and handmade crafts are sold, allows for an authentic experience of the town's culture. Finally, attending local festivals, particularly the Carnaval and Fiesta de la Virgen de la Asunción, can enrich one’s understanding of Huajuapan's traditions and community spirit.