South Padre Island offers a range of activities that cater to various interests. One of the most popular attractions is the beaches, where visitors can enjoy sunbathing, swimming, and beachcombing along the Gulf of Mexico's coastline. Water sports are also a significant draw, with opportunities for kayaking, paddleboarding, and jet skiing. For those interested in marine life, dolphin watching tours provide a chance to see these creatures in their natural habitat, often coupled with stunning views of the coastline.

Another highlight is the South Padre Island Birding and Nature Center, which features trails, boardwalks, and observation towers that allow for birdwatching and enjoying the local flora and fauna. Fishing is a popular activity as well, with options for both shore fishing and chartering a boat for deep-sea fishing experiences.

For a unique experience, visitors can explore the Sea Turtle, Inc. facility, which focuses on the rescue and rehabilitation of sea turtles. Engaging with the educational programs here can be both informative and inspiring. The local nightlife offers a variety of bars and restaurants, where visitors can sample fresh seafood and enjoy live music.

The island also hosts several festivals throughout the year, celebrating everything from music to food, which can provide an interesting cultural experience. Finally, for those seeking relaxation, many resorts and spas offer wellness treatments, making it a suitable destination for unwinding.